• Source: CCL3

Chemokine (C-C motif) ligand 3 (CCL3) also known as macrophage inflammatory protein 1-alpha (MIP-1-alpha) is a protein that in humans is encoded by the CCL3 gene.




Function


CCL3 is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes through binding to the receptors CCR1, CCR4 and CCR5.
Sherry et al. (1988) demonstrated 2 protein components of MIP1, called by them alpha (CCL3, this protein) and beta (CCL4).
CCL3 produces a monophasic fever of rapid onset whose magnitude is equal to or greater than that of fevers produced with either recombinant human tumor necrosis factor or recombinant human interleukin-1. However, in contrast to these two endogenous pyrogens, the fever induced by MIP-1 is not inhibited by the cyclooxygenase inhibitor ibuprofen and CCL3 may participate in the febrile response that is not mediated through prostaglandin synthesis and clinically cannot be ablated by cyclooxygenase.




Interactions


CCL3 has been shown to interact with CCL4.
Attracts macrophages, monocytes and neutrophils.




See also


Macrophage inflammatory proteins




References






External links


Human CCL3 genome location and CCL3 gene details page in the UCSC Genome Browser.




Further reading

Kata Kunci Pencarian:

• Hidrat
• Kloroform
• Substitusi elektrofilik aromatik
• Imunoterapi
• Daftar gen penyandi protein pada manusia/1
• Asil klorida
• CCL3
• Macrophage inflammatory protein
• Chemokine
• Reaction intermediate
• Hydrate
• Phenyl(trichloromethyl)mercury
• Trichloromethyl group
• Deuterated chloroform
• Terephthaloyl chloride
• Haloform reaction