- Source: CEACAM5
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) also known as CD66e (Cluster of Differentiation 66e), is a member of the carcinoembryonic antigen (CEA) gene family.
Functions
In the literature, CEACAM5 is often used as a synonym for cancer embryonic antigen (CEA), a well-known biomarker of many types of malignancies, such as colorectal cancer and non-small-cell lung cancer. Its primary function in the embryonic intestine and colon tumors is adhesion between epithelial cells. Also, it plays a significant role in the inhibition of differentiation and apoptosis in colon cells. There are evidences that high CEACAM5 expression is firmly associated with the CD133-positive colorectal cancer stem cells. High CEACAM5 expression has also been identified in ~25% of patients with advanced non-squamous (NSq) non-small cell lung cancer (NSCLC) detectable via IHC (immunohistochemistry).
See also
Cluster of differentiation
References
Further reading
External links
CEACAM5+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human CEACAM5 genome location and CEACAM5 gene details page in the UCSC Genome Browser.
PDBe-KB provides an overview of all the structure information available in the PDB for Human Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Kata Kunci Pencarian:
- Daftar gen penyandi protein pada manusia/1
- CEACAM5
- List of human protein-coding genes 1
- Carcinoembryonic antigen
- Immunomedics
- List of therapeutic monoclonal antibodies
- List of human clusters of differentiation
- Immunoglobulin domain
- Immunoglobulin V-set domain
- Outline of immunology
