- Source: CLDN18
Claudin-18 is a protein that in humans is encoded by the CLDN18 gene. It belongs to the group of claudins.
CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells . [supplied by OMIM]
Clinical significance
Isoform 2 (Claudin 18.2) is abundant in gastric tumors.
Zolbetuximab targets Claudin 18.2 to help treat gastric cancers.
References
External links
Human CLDN18 genome location and CLDN18 gene details page in the UCSC Genome Browser.
Further reading
Kata Kunci Pencarian:
- Daftar gen penyandi protein pada manusia/1
- CLDN18
- Zolbetuximab
- Astellas Pharma
- List of human protein-coding genes 1
- Claudin
