- Source: Clozapine N-oxide
Clozapine N-oxide (CNO) is a synthetic drug used mainly in biomedical research as a ligand to activate Designer Receptors Exclusively Activated by Designer Drugs (DREADDs), despite the initial belief that it was biologically inert. However, it has been shown to not enter the brain after administration and to reverse metabolize in peripheral tissues to form clozapine. Clozapine can bind to a number of different serotonergic, dopaminergic and adrenergic receptors within the brain. These off-target effects mean behavioral data using the CNO-DREADD system have to be interpreted with caution.
Alternatives to CNO with more affinity, more inert character, and faster kinetics include Compound 21 (C21) and deschloroclozapine (DCZ).
References
Kata Kunci Pencarian:
- Clozapine N-oxide
- Receptor activated solely by a synthetic ligand
- CNO
- Clozapine
- Nitrous oxide
- Behavioral neuroscience
- Synthetic biology
- Controlled Drugs and Substances Act
- Hippocampal replay
- Fiber photometry
