• Source: Cob(II)yrinic acid a,c-diamide reductase

In enzymology, a cob(II)yrinic acid a,c-diamide reductase (EC 1.16.8.1) is an enzyme that catalyzes the chemical reaction

The three substrates of this enzyme are cob(I)yrinic acid a,c-diamide, flavin mononucleotide, and H+; its two products are cob(II)yrinic acid a,c-diamide and FMNH2.




Classification


This enzyme belongs to the family of oxidoreductases, specifically those oxidizing metal ion with a flavin as acceptor.




Nomenclature


The systematic name of this enzyme class is cob(I)yrinic acid-a,c-diamide:FMN oxidoreductase. This enzyme is also called CobR and cob(II)yrinic acid-a,c-diamide:FMN oxidoreductase (incorrect).




Biological role


This enzyme is part of the biosynthetic pathway to cobalamin (vitamin B12) in bacteria.




See also


Cobalamin biosynthesis




References



Blanche F, Maton L, Debussche L, Thibaut D (1992). "Purification and characterization of Cob(II)yrinic acid a,c-diamide reductase from Pseudomonas denitrificans". J. Bacteriol. 174 (22): 7452–4. PMC 207442. PMID 1429467.
Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC (2002). "The biosynthesis of adenosylcobalamin (vitamin B12)". Nat. Prod. Rep. 19 (4): 390–412. doi:10.1039/b108967f. PMID 12195810.

Kata Kunci Pencarian:

• Cob(II)yrinic acid a,c-diamide reductase
• Nitroreductase
• Cobalamin biosynthesis
• List of EC numbers (EC 2)