- Source: Cobalt-precorrin-7 (C15)-methyltransferase (decarboxylating)
Cobalt-precorrin-7 (C15)-methyltransferase (decarboxylating) (EC 2.1.1.196, CbiT) is an enzyme with systematic name S-adenosyl-L-methionine:precorrin-7 C15-methyltransferase (C12-decarboxylating). This enzyme catalyses the following chemical reaction
cobalt-precorrin-7 + S-adenosyl-L-methionine
⇌
{\displaystyle \rightleftharpoons }
cobalt-precorrin-8x + S-adenosyl-L-homocysteine + CO2
This enzyme catalyses both methylation at C-15 and decarboxylation of the C-12 acetate side chain of cobalt-precorrin-7 in the anaerobic pathway of adenosylcobalamin biosynthesis in bacteria such as Salmonella typhimurium, Bacillus megaterium, and Propionibacterium freudenreichii subsp. shermanii.
See also
Cobalamin biosynthesis
References
External links
Cobalt-precorrin-7+(C15)-methyltransferase+(decarboxylating) at the U.S. National Library of Medicine Medical Subject Headings (MeSH)