- Source: CORIN
Corin, also called atrial natriuretic peptide-converting enzyme, is a protein that in humans is encoded by the CORIN gene.
Protein
Human corin, a polypeptide of 1042 amino acids, consists of an N-terminal cytoplasmic domain, a transmembrane domain and an extracellular region with two frizzled-like domains, eight LDL receptor-like domains, a scavenger receptor-like domain and a C-terminal trypsin-like serine protease domain. Corin is synthesized as a zymogen that is activated by PCSK6.
Corin exhibits a trypsin-like catalytic activity favoring basic residues at the P1 position.
Human corin contains 19 N-glycosylation sites. N-glycans promote corin expression on the cell surface and protect corin from metalloproteinase-mediated shedding.
Function
Corin converts the atrial natriuretic peptide (ANP) precursor, pro-ANP, to mature ANP, a cardiac hormone that regulates salt-water balance and blood pressure. In mice, corin deficiency prevents pro-ANP processing and causes salt-sensitive hypertension.
Corin may also function as a pro-brain-type natriuretic peptide convertase.
Corin-mediated ANP production in the pregnant uterus promotes spiral artery remodeling and trophoblast invasion. CORIN mutations have been reported in patients with preeclampsia.
In mice, corin functions in the dermal papilla to regulate coat color in an Agouti-dependent pathway.
Variants and mutations
Variants encoded by alternative exons were reported in human and mouse corin. A variant allele (T555I/Q568P) was found in African Americans with hypertension and cardiac hypertrophy. The amino acid substitutions impaired corin activity. An insertion variant in exon 1 alters the cytoplasmic tail. This variant appeared more frequently in hypertensive patients. CORIN mutations were found in patients with hypertension.
References
Further reading
External links
Human CORIN genome location and CORIN gene details page in the UCSC Genome Browser.- Source: Corin
Corin is a given name in English deriving from the Latin Quirinus, a Roman god. The meaning is unclear but is probably associated with "spear".
It is used as a masculine or feminine given name, and also as a surname.
Given name
Corin Braga (born 1961), Romanian writer and academic
Corin Hewitt (born 1971), American sculptor and photographer
Corin Ileto, stage name CORIN, Filipina-Australian electronic producer, composer and performer, performed at 2023 Unsound Adelaide
Corin Mellor (born 1966), British designer
Corin Nemec (born 1971), American actor
Corin Redgrave (1939–2010), British actor and political activist
Corin Tucker (born 1972), American singer and guitarist
Surname
Jaclyn Corin (born 2000), American activist and advocate for gun control
Lucy Corin, American writer
William Corin (1867–1929), Australian electrical engineer
Fictional characters
Corin, a character in William Shakespeare's play As You Like It
Corin Thunderfist, fictional character and twin of Cor in The Chronicles of Narnia
Related names
Corina, including Corine and Coreen
Korin (disambiguation)
Coryn (name)
Corran (disambiguation)
Chorin (surname)
References
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