• Source: Coumaroyl-CoA

Coumaroyl-coenzyme A is the thioester of coenzyme-A and coumaric acid. Coumaroyl-coenzyme A is a central intermediate in the biosynthesis of myriad natural products found in plants. These products include lignols (precursors to lignin and lignocellulose), flavonoids, isoflavonoids, coumarins, aurones, stilbenes, catechin, and other phenylpropanoids.




Biosynthesis and significance


It is generated in nature from phenylalanine, which is converted by PAL to trans-cinnamate. Trans-cinnamate is hydroxylated by trans-cinnamate 4-monooxygenase to give 4-hydroxycinnamate (i.e, coumarate). Coumarate is condensed with coenzyme-A in the presence of 4-coumarate-CoA ligase:

ATP + 4-coumarate + CoA



⇌


{\displaystyle \rightleftharpoons }

AMP + diphosphate + 4-coumaroyl-CoA.




Enzymes using Coumaroyl-Coenzyme A


Anthocyanin 3-O-glucoside 6''-O-hydroxycinnamoyltransferase
Anthocyanin 5-aromatic acyltransferase
Chalcone synthase
4-Coumarate-CoA ligase
6'-Deoxychalcone synthase
Agmatine N4-coumaroyltransferase
Flavonol-3-O-triglucoside O-coumaroyltransferase
Naringenin-chalcone synthase
Shikimate O-hydroxycinnamoyltransferase
Trihydroxystilbene synthase




References

Kata Kunci Pencarian:

• Raspberry ketone
• Coumaroyl-CoA
• Malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)
• 4-Coumarate-CoA ligase
• P-Coumaric acid
• Phenylpropanoid
• Shikimate O-hydroxycinnamoyltransferase
• Kaempferol
• Fisetin
• Apigenin
• Quercetin