• Source: Dichloropane

    • Dichloropane ((−)-2β-Carbomethoxy-3β-(3,4-dichlorophenyl)tropane, RTI-111, O-401) is a stimulant of the phenyltropane class that acts as a serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI) with IC50 values of 3.13, 18, and 0.79 nM, respectively. In animal studies, dichloropane had a slower onset and longer duration of action compared to cocaine.
    Methylecgonidine is the direct precursor to this compound.


    Trans -CO2Me group


    The thermodynamic isomer with a trans -CO2Me group is still active. This isomer was used by Neurosearch to make three different phenyltropanes which were tested in clinical trials.

    Tesofensine
    Brasofensine
    NS-2359 (GSK-372,475)


    See also


    3,4-DCMP
    O-2390
    List of cocaine analogues
    List of phenyltropanes


    References

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