• Source: Disease vector

In epidemiology, a disease vector is any living agent that carries and transmits an infectious pathogen such as a parasite or microbe, to another living organism. Agents regarded as vectors are mostly blood-sucking insects such as mosquitoes. The first major discovery of a disease vector came from Ronald Ross in 1897, who discovered the malaria pathogen when he dissected the stomach tissue of a mosquito.




Arthropods



Arthropods form a major group of pathogen vectors with mosquitoes, flies, sand flies, lice, fleas, ticks, and mites transmitting a huge number of pathogens. Many such vectors are haematophagous, which feed on blood at some or all stages of their lives. When the insects feed on blood, the pathogen enters the blood stream of the host. This can happen in different ways.
The Anopheles mosquito, a vector for malaria, filariasis, and various arthropod-borne-viruses (arboviruses), inserts its delicate mouthpart under the skin and feeds on its host's blood. The parasites the mosquito carries are usually located in its salivary glands (used by mosquitoes to anaesthetise the host). Therefore, the parasites are transmitted directly into the host's blood stream. Pool feeders such as the sand fly and black fly, vectors for pathogens causing leishmaniasis and onchocerciasis respectively, will chew a well in the host's skin, forming a small pool of blood from which they feed. Leishmania parasites then infect the host through the saliva of the sand fly. Onchocerca force their own way out of the insect's head into the pool of blood.
Triatomine bugs are responsible for the transmission of a trypanosome, Trypanosoma cruzi, which causes Chagas disease. The Triatomine bugs defecate during feeding and the excrement contains the parasites, which are accidentally smeared into the open wound by the host responding to pain and irritation from the bite.
There are several species of Thrips that act as vectors for over 20 viruses, especially Tospoviruses, and cause all sorts of plant diseases.




Plants and fungi


Some plants and fungi act as vectors for various pathogens. For example, the big-vein disease of lettuce was long thought to be caused by a member of the fungal division Chytridiomycota, namely Olpidium brassicae. Eventually, however, the disease was shown to be viral. Later it transpired that the virus was transmitted by the zoospores of the fungus and also survived in the resting spores. Since then, many other fungi in Chytridiomycota have been shown to vector plant viruses.
Many plant pests that seriously damage important crops depend on other plants, often weeds, to harbour or vector them; the distinction is not always clear. In the case of Puccinia graminis for example, Berberis and related genera act as alternate hosts in a cycle of infection of grain.
More directly, when they twine from one plant to another, parasitic plants such as Cuscuta and Cassytha have been shown to convey phytoplasmal and viral diseases between plants.




Mammals


Rabies is transmitted through exposure to the saliva or brain tissue of an infected animal. Any warm-blooded animal can carry rabies, but the most common vectors are dogs, skunks, raccoons, and bats.




Vector-borne zoonotic disease and human activity



Several articles, recent to early 2014, warn that human activities are spreading vector-borne zoonotic diseases. Several articles were published in the medical journal The Lancet, and discuss how rapid changes in land use, trade globalization, climate change and "social upheaval" are causing a resurgence in zoonotic disease across the world.
Examples of vector-borne zoonotic diseases include:

Lyme disease
Plague
West Nile virus
Many factors affect the incidence of vector-borne diseases. These factors include animals hosting the disease, vectors, and people.
Humans can also be vectors for some diseases, such as Tobacco mosaic virus, physically transmitting the virus with their hands from plant to plant.




Control and prevention



The World Health Organization (WHO) states that control and prevention of vector-borne diseases are emphasizing "Integrated Vector Management (IVM)", which is an approach that looks at the links between health and environment, optimizing benefits to both.
In April 2014, WHO launched a campaign called "Small bite, big threat" to educate people about vector-borne illnesses. WHO issued reports indicating that vector-borne illnesses affect poor people, especially people living in areas that do not have adequate levels of sanitation, drinking water and housing. It is estimated that over 80% of the world's population resides in areas under threat of at least one vector borne disease.




See also


Airborne disease
Asymptomatic carrier
Fomite
Globalization and disease
Insect vectors of human pathogens
Insect vectors of plant pathogens
VectorBase: genomic database of invertebrate vectors of human pathogens
List of diseases caused by insects
Natural reservoir
Waterborne disease
2007 Yap Islands Zika virus outbreak




Notes






References






External links


WHO page on vector-borne diseases

Biological mosquito eradication in Monte Verde, Honduras
The National Center for Biotechnology Information, Vector-borne Diseases: Understanding the Environmental, Human Health, and Ecological Connections
Science Direct, Current Research in Parasitology and Vector-borne Diseases
CDC Diseases Carried by Vectors

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• Aedes albopictus
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