• Source: DLGAP1

Disks large-associated protein 1 (DAP-1), also known as guanylate kinase-associated protein (GKAP), is a protein that in humans is encoded by the DLGAP1 gene. DAP-1 is known to be highly enriched in synaptosomal preparations of the brain, and present in the post-synaptic density.




Function


This gene encodes the protein called guanylate kinase-associated protein (GKAP). GKAP binds to the SHANK2 and PSD-95 proteins, facilitating the assembly of the post-synaptic density of neurons. Dlgap1 has five 14-amino-acid repeats and three Pro-rich portions.




Interactions


DLGAP1 has been shown to interact with:

DLG1
DLG4
DYNLL1
DYNLL2
SHANK2
The interaction with PSD95 and S-SCAM is mediated by the GUK domain and it has been hypothesized that this might mean it can also interact with other GUK containing proteins.




References






Further reading

Kata Kunci Pencarian:

• Daftar gen penyandi protein pada manusia/1
• DLGAP1
• List of human protein-coding genes 1
• Obsessive–compulsive disorder
• DLG4
• DYNLL2
• SHANK2
• DYNLL1