• Source: DMAP1

DNA methyltransferase 1-associated protein 1 is an enzyme that in humans is encoded by the DMAP1 gene.




Function


This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.




Interactions


DMAP1 has been shown to interact with:

C19orf2,
DNMT1,
ING1, and
RGS6




References






Further reading

Kata Kunci Pencarian:

• Daftar gen penyandi protein pada manusia/1
• DMAP1
• RGS6
• List of human protein-coding genes 1
• DNMT1
• Proliferating cell nuclear antigen
• TSG101
• SBK3
• Incheol Shin
• URI1
• ING1