• Source: DNA-formamidopyrimidine glycosylase

DNA-formamidopyrimidine glycosylase (EC 3.2.2.23, Fapy-DNA glycosylase, deoxyribonucleate glycosidase, 2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase, 2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase, formamidopyrimidine-DNA glycosylase, DNA-formamidopyrimidine glycosidase, Fpg protein) is an enzyme with systematic name DNA glycohydrolase (2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing). FPG is a base excision repair enzyme which recognizes and removes a wide range of oxidized purines from correspondingly damaged DNA. It was discovered by Zimbabwean scientist Christopher J. Chetsanga in 1975.
This enzyme catalyses the following chemical reaction

Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine
This enzyme participates in processes leading to recovery from mutagenesis and/or cell death by alkylating agents.




References






External links


DNA-formamidopyrimidine+glycosylase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Kata Kunci Pencarian:

• DNA-formamidopyrimidine glycosylase
• DNA glycosylase
• Base excision repair
• FPG
• H2TH domain
• DNA oxidation
• NEIL1
• NTHL1
• Werner syndrome helicase
• Reactive oxygen species