• Source: DYRK1B

Dual specificity tyrosine-phosphorylation-regulated kinase 1B is an enzyme that in humans is encoded by the DYRK1B gene.




Function


DYRK1B is a member of the DYRK family of protein kinases. DYRK1B contains a bipartite nuclear localization signal and is found mainly in muscle and testis. The protein is proposed to be involved in the regulation of nuclear functions. Three isoforms of DYRK1B have been identified differing in the presence of two alternatively spliced exons within the catalytic domain.




Interactions


DYRK1B has been shown to interact with:

PCBD1 and
RANBP9.




Clinical significance


One lone missense mutation in Dyrk1B gene (R102C) was found associated with an autosomal dominant early onset Coronary Artery Disease, juvenile-onset truncal obesity, severe hypertension, and type II diabetes mellitus - seen in subjects from a nomadic group in Iran.




See also


DYRK1A
DYRK2




References






Further reading

Kata Kunci Pencarian:

• Daftar gen penyandi protein pada manusia/1
• DYRK1B
• DYRK (disambiguation)
• List of human protein-coding genes 1
• DYRK1A
• Protein kinase domain
• KIAA0232
• Dual-specificity kinase
• PCBD1
• RANBP9
• CEFIP