• Source: EBI3

Epstein-Barr virus induced gene 3, also known as interleukin-27 subunit beta or IL-27B, is a protein which in humans is encoded by the EBI3 gene.




Function


This gene was identified by the induction of its expression in B lymphocytes by Epstein–Barr virus infection. The protein encoded by this gene is a secreted glycoprotein, which is a member of the hematopoietin receptor family related to the p40 subunit of interleukin 12 (IL-12). It plays a role in regulating cell-mediated immune responses.
EBI3 is a subunit in 2 distinct heterodimeric cytokines: interleukin-27 (IL27) and IL35. IL27 is composed of p28 (IL27) and EBI3. IL27 can trigger signaling in T cells, B cells, and myeloid cells. IL35, an inhibitory cytokine involved in regulatory T-cell function, is composed of EBI3 and the p35 subunit of IL12.




References






Further reading






External links


EBI3 human gene location in the UCSC Genome Browser.
EBI3 human gene details in the UCSC Genome Browser.

Kata Kunci Pencarian:

• Daftar gen penyandi protein pada manusia/1
• EBI3
• Interleukin 30
• List of human protein-coding genes 1
• Interleukin 27
• Interleukin 35
• Fibronectin type III domain
• Minor histocompatibility antigen
• CCDC94
• ANKRD24
• Interleukin 27 receptor, alpha subunit