- Source: EIF-2 kinase
eIF-2-alpha kinase is a kinase enzyme that phosphorylates eIF2α. There are four forms in mammals:
EIF2AK1: heme-regulated inhibitor kinase (HRI)
EIF2AK2: the double-stranded RNA-dependent kinase (protein kinase R, PKR)
EIF2AK3: also known as "PKR-like endoplasmic reticulum kinase" (PEK/PERK)
EIF2AK4: also known as GCN2
These are all responsible for the phosphorylation of the alpha subunit of eIF-2 at serine 51, one of the best-characterized mechanisms for down-regulating protein synthesis in eukaryotes as a part of cellular stress response.
References
Kata Kunci Pencarian:
- EIF-2 kinase
- Protein kinase A
- CAMK
- Serine/threonine-specific protein kinase
- Mitogen-activated protein kinase kinase
- Mitogen-activated protein kinase
- AMP-activated protein kinase
- Cyclin-dependent kinase 2
- Protein kinase C
- Cyclin-dependent kinase
