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    • Source: ELOC
    • Elongin C is a protein that in humans is encoded by the ELOC gene.


      Function


      Elongin C is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation.


      Interactions


      TCEB1 has been shown to interact with:

      TCEB2 and
      Von Hippel-Lindau tumor suppressor.


      References




      Further reading

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