- Source: Emde degradation
The Emde degradation (also called Emde-reaction or Emde-reduction) is a method for the reduction of a quaternary ammonium cation to a tertiary amine with sodium amalgam:
This organic reaction was first described in 1909 by the German chemist Hermann Emde and was for a long time of great importance in structure elucidation of many alkaloids, for example that of ephedrine.
Alternative reducing agents exist for this reaction; for instance, lithium aluminium hydride.
See also
Related reactions are the Hofmann elimination and the von Braun reaction
References
Kata Kunci Pencarian:
- Emde degradation
- Emde
- Sodium amalgam
- Amine
- List of organic reactions
- Hofmann elimination
- Quaternary ammonium cation
- RXNO Ontology
- History and culture of substituted amphetamines
- Ozone depletion
