- Source: Estrogen-related receptor
The ERRs are orphan nuclear receptors, meaning the identity of their endogenous ligand has yet to be unambiguously determined. They are named because of sequence homology with estrogen receptors, but do not appear to bind estrogens or other tested steroid hormones.
There are three human estrogen related receptors:
ERRα (ESRRA)
ERRβ (ESRRB)
ERRγ (ESRRG)
ERRs bind enhancers throughout the genome where they exert effects on gene regulation. The ERR family exhibit varying transcriptional activation capabilities and physically interact with the transcriptional co-activators PGC1-alpha and PGC1-beta, via their AF-2 domains and the leucine-rich nuclear receptor interacting motifs (LxxLL) present in the PGC-1 proteins, The ERR family have been demonstrated to control energy homeostasis, oxidative metabolism, and mitochondrial biogenesis, while effecting mammalian physiology in the heart, brown adipose tissue, white adipose tissue, placenta, macrophages, and demonstrated additional roles in diabetes and cancer. The contributions of individual ERRs to physiology continue to be elucidated through the generation of sophisticated tissue-specific gene knockout mouse models.
References
External links
ERRalpha+estrogen-related+receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
estrogen+receptor-related+receptor+beta at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
ESRRB+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
ESRRG+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Kata Kunci Pencarian:
- Noretisteron
- Kontrasepsi hormonal
- Sistem imun
- Glukokortikoid
- Finasterid
- BRCA1
- Kanker
- Faktor pertumbuhan saraf
- Kemandulan pada wanita
- Estrogen-related receptor
- Estrogen-related receptor alpha
- Estrogen-related receptor gamma
- Estrogen-related receptor beta
- Estrogen receptor
- Estrogen receptor alpha
- Selective estrogen receptor modulator
- Estrogen receptor beta
- Membrane estrogen receptor
- Steroid hormone receptor
