- Source: Fluorocitric acid
Fluorocitric acid is an organic compound with the chemical formula HOC(CO2H)(CH2CO2H)(CHFCO2H). It is a fluorinated carboxylic acid derived from citric acid by substitution of one methylene hydrogen by a fluorine atom. The appropriate anion is called fluorocitrate. Fluorocitrate is formed in two steps from fluoroacetate. Fluoroacetate is first converted to fluoroacetyl-CoA by acetyl-CoA synthetase in the mitochondria. Then fluoroacetyl-CoA condenses with oxaloacetate to form fluorocitrate. This step is catalyzed by citrate synthase. Flurocitrate is a metabolite of fluoroacetic acid and is very toxic because it is not processable using aconitase in the citrate cycle (where fluorocitrate takes place of citrate as the substrate). The enzyme is inhibited and the cycle stops working.
See also
Citric acid
Fluoroacetic acid
Citrate cycle
References
External links
PubChem: Fluorocitrate
Human Metabolome Database (HMDB): Fluorocitric acid Archived 2016-03-04 at the Wayback Machine
The Chemical and Biochemical Properties of Fluorocitric Acid Pdf
