- Source: Formimidoyltransferase cyclodeaminase
Formimidoyltransferase cyclodeaminase or formiminotransferase cyclodeaminase (gene symbol FTCD in humans) is a bifunctional enzyme that catalyzes the following reactions:
conversion of formiminoglutamate and tetrahydrofolate into formiminotetrahydrofolate and glutamate (glutamate formimidoyltransferase activity, EC 2.1.2.5)
subsequent deamination of formiminotetrahydrofolate to 5,10-methenyltetrahydrofolate and ammonia (formimidoyltetrahydrofolate cyclodeaminase activity, EC 4.3.1.4)
Its name comes from the two activities it catalyzes.
Role in pathology
Mutations of the FTCD gene cause glutamate formiminotransferase deficiency.
See also
Glutamate-1-semialdehyde
References
Kata Kunci Pencarian:
- Formimidoyltransferase cyclodeaminase
- Working memory
- Glutamate formimidoyltransferase
- Chromosome 21
- Formimidoyltetrahydrofolate cyclodeaminase
- FTCD (disambiguation)
- 5-Formiminotetrahydrofolate
