- Source: Frizzled-4
Frizzled-4 (Fz-4) is a protein that in humans is encoded by the FZD4 gene. Fz-4 has also been designated as CD344 (cluster of differentiation 344).
Function
This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Frizzled-4 is the only representative of frizzled family members that binds strongly an additional ligand Norrin that is functionally similar but structurally different from Wingless type proteins. FZD4 signaling induced by Norrin regulates vascular development of vertebrate retina and controls important blood vessels in the ear. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence.
See also
Frizzled
References
Further reading
External links
"Frizzled Receptors: FZD4". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-04.]
GeneReviews/NCBI/NIH/UW entry on Familial Exudative Vitreoretinopathy, Autosomal Dominant
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Kata Kunci Pencarian:
- Protein morfogenetik tulang 1
- Reseptor terhubung protein G
- Reseptor terhubung-protein G adhesi
- Frizzled-4
- Frizzled
- Frizzle Fry
- Frizzle (chicken breed)
- Secreted frizzled-related protein 1
- The Magic School Bus
- SFRP4
- Osteoporosis-pseudoglioma syndrome
- Norrin
- Frizzled-5
