- Source: Gastrin-releasing peptide receptor
The gastrin-releasing peptide receptor (GRPR), now properly known as BB2 is a G protein-coupled receptor whose endogenous ligand is gastrin releasing peptide. In humans it is highly expressed in the pancreas and is also expressed in the stomach, adrenal cortex and brain.
Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.
The transcription factor CREB is a regulator of human GRP-R expression in colon cancer.
Activation MOR1D‐GRPR heteromers in the spinal cord mediate the common troublesome opioid-induced itch.
References
Further reading
External links
"Bombesin Receptors: BB2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2007-10-25.
IUPHAR GPCR Database - BB2 receptor Archived 2016-03-03 at the Wayback Machine
Receptors,+Bombesin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Kata Kunci Pencarian:
- Gastrin
- Gastrin-releasing peptide receptor
- Gastrin-releasing peptide
- Gastrin
- Pro-gastrin-releasing-peptide
- Peptide hormone
- Gastric inhibitory polypeptide receptor
- Cholecystokinin receptor
- Gonadotropin-releasing hormone
- Vasoactive intestinal peptide
- Corticotropin-releasing hormone
