• Source: GBA3

      • Cytosolic beta-glucosidase, also known as cytosolic beta-glucosidase-like protein 1, is a beta-glucosidase (EC 3.2.1.21) enzyme that in humans is encoded by the GBA3 gene.


      Function


      Cytosolic beta-glucosidase is a predominantly liver enzyme that efficiently hydrolyzes beta-D-glucoside and beta-D-galactoside, but not any known physiologic beta-glycoside, suggesting that it may be involved in detoxification of plant glycosides. GBA3 also has significant neutral glycosylceramidase activity (EC 3.2.1.62), suggesting that it may be involved in a non-lysosomal catabolic pathway of glucosylceramide metabolism.


      See also


      Closely related enzymes
      GBA: acid β-glucosidase, EC 3.2.1.45
      GBA2: acid β-glucosidase (bile acid), also EC 3.2.1.45


      References




      Further reading




      External links


      PDBe-KB provides an overview of all the structure information available in the PDB for Human Cytosolic beta-glucosidase

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