• Source: Gentisic acid

Gentisic acid is a dihydroxybenzoic acid. It is a derivative of benzoic acid and a minor (1%) product of the metabolic break down of aspirin, excreted by the kidneys.
It is also found in the African tree Alchornea cordifolia and in wine.




Production


Gentisic acid is produced by carboxylation of hydroquinone.

C6H4(OH)2 + CO2 → C6H3(CO2H)(OH)2
This conversion is an example of a Kolbe–Schmitt reaction.
Alternatively the compound can be synthesized from salicylic acid via Elbs persulfate oxidation.




Reactions


In the presence of the enzyme gentisate 1,2-dioxygenase, gentisic acid reacts with oxygen to give maleylpyruvate:

2,5-dihydroxybenzoate + O2



⇌


{\displaystyle \rightleftharpoons }

maleylpyruvate




Applications


As a hydroquinone, gentisic acid is readily oxidised and is used as an antioxidant excipient in some pharmaceutical preparations.
In the laboratory, it is used as a sample matrix in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry, and has been shown to conveniently detect peptides incorporating the boronic acid moiety by MALDI.




References






Cited sources


Haynes, William M., ed. (2016). CRC Handbook of Chemistry and Physics (97th ed.). CRC Press. ISBN 9781498754293.

Kata Kunci Pencarian:

• Gentisic acid
• Aspirin
• Dihydroxybenzoic acid
• 3-Maleylpyruvic acid
• Matrix-assisted laser desorption/ionization
• Alchornea cordifolia
• Euxanthone
• Cocrystal
• Phenolic content in wine
• 2,5-Dihydroxycinnamic acid