• Source: GGA2

ADP-ribosylation factor-binding protein GGA2 is a protein that in humans is encoded by the GGA2 gene.




Function


This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly.




Interactions


GGA2 has been shown to interact with RABEP1, Sortilin 1, BACE2 and CLINT1.




References






Further reading

Kata Kunci Pencarian:

• Daftar gen penyandi protein pada manusia/2
• GGA2
• Beta-secretase 2
• List of human protein-coding genes 2
• Sortilin 1
• Microchromosome
• GGA1
• CLINT1
• RABEP1