- Source: Glucosamine-1-phosphate N-acetyltransferase
In enzymology, a glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157) is an enzyme that catalyzes the chemical reaction
acetyl-CoA + alpha-D-glucosamine 1-phosphate
⇌
{\displaystyle \rightleftharpoons }
CoA + N-acetyl-alpha-D-glucosamine 1-phosphate
Thus, the two substrates of this enzyme are acetyl-CoA and alpha-D-glucosamine 1-phosphate, whereas its two products are CoA and N-acetyl-alpha-D-glucosamine 1-phosphate.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:alpha-D-glucosamine-1-phosphate N-acetyltransferase. This enzyme participates in aminosugars metabolism.
Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2OI5, 2OI6, and 2OI7.
References
Mengin-Lecreulx D, van Heijenoort J (1994). "Copurification of glucosamine-1-phosphate acetyltransferase and N-acetylglucosamine-1-phosphate uridyltransferase activities of Escherichia coli: characterization of the glmU gene product as a bifunctional enzyme catalyzing two subsequent steps in the pathway for UDP-N-acetylglucosamine synthesis". J. Bacteriol. 176 (18): 5788–95. doi:10.1128/jb.176.18.5788-5795.1994. PMC 196783. PMID 8083170.
Kata Kunci Pencarian:
- Glucosamine-1-phosphate N-acetyltransferase
- Glucosamine-phosphate N-acetyltransferase
- N-acetyltransferase
- Aralkylamine N-acetyltransferase
- List of EC numbers (EC 2)
- Protein O-GlcNAc transferase
- UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine transaminase
- Hyaluronic acid
- Cell-free protein synthesis
- Index of molecular biology articles
