- Source: Glycine formimidoyltransferase
In enzymology, a glycine formimidoyltransferase (EC 2.1.2.4) is an enzyme that catalyzes the chemical reaction
5-formimidoyltetrahydrofolate + glycine
⇌
{\displaystyle \rightleftharpoons }
tetrahydrofolate + N-formimidoylglycine
Thus, the two substrates of this enzyme are 5-formimidoyltetrahydrofolate and glycine, whereas its two products are tetrahydrofolate and N-formimidoylglycine.
This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the hydroxymethyl-, formyl- and related transferases. The systematic name of this enzyme class is 5-formimidoyltetrahydrofolate:glycine N-formimidoyltransferase. Other names in common use include formiminoglycine formiminotransferase, FIG formiminotransferase, and glycine formiminotransferase. This enzyme participates in purine metabolism and one carbon pool by folate.
References
Rabinowitz JC; Pricer WE (1956). "Formiminotetrahydrofolic acid and methenyltetrahydrofolic acid as intermediates in the formation of N10-formyltetrahydrofolic acid". J. Am. Chem. Soc. 78 (21): 5702–5704. doi:10.1021/ja01602a073.
Rabinowitz JC; Pricer WE (1957). "Formation, isolation and properties of 5-formiminotetrahydrofolic acid". Fed. Proc. 16: 236.
Sagers RD, Beck JV, Gruber W, Gunsalus IC (1956). "A tetrahydrofolic acid linked formimino transfer enzyme". J. Am. Chem. Soc. 78: 694–695. doi:10.1021/ja01584a054.
