• Source: Glycogen synthase kinase-3 beta

3/info/glycogen" target="_blank">Glycogen 3/info/synthase" target="_blank">synthase 3/info/kinase" target="_blank">kinase-3 beta, (GSK-3 beta), is an enzyme that in humans is encoded by the GSK3B gene. In mice, the enzyme is encoded by the Gsk3b gene. Abnormal regulation and expression of GSK-3 beta is associated with an increased susceptibility towards bipolar disorder.




Function


3/info/glycogen" target="_blank">Glycogen 3/info/synthase" target="_blank">synthase 3/info/kinase" target="_blank">kinase-3 (GSK-3) is a proline-directed serine-threonine 3/info/kinase" target="_blank">kinase that was initially identified as a phosphorylating and an inactivating agent of 3/info/glycogen" target="_blank">glycogen 3/info/synthase" target="_blank">synthase. Two isoforms, alpha (GSK3A) and beta, show a high degree of amino acid homology. GSK3B is involved in energy metabolism, neuronal cell development, and body pattern formation. It might be a new therapeutic target for ischemic stroke.




Disease relevance


Homozygous disruption of the Gsk3b locus in mice results in embryonic lethality during mid-gestation. This lethality phenotype could be rescued by inhibition of tumor necrosis factor.
Two SNPs at this gene, rs334558 (-50T/C) and rs3755557 (-1727A/T), are associated with efficacy of lithium treatment in bipolar disorder.




Signaling pathways


Pharmacological inhibition of ERK1/2 restores GSK-3 beta activity and protein synthesis levels in a model of tuberous sclerosis.




Interactions


GSK3B has been shown to interact with:

KIAA1211L
ATP2A2




See also


3/info/glycogen" target="_blank">Glycogen 3/info/synthase" target="_blank">synthase 3/info/kinase" target="_blank">kinase 3




References






Further reading






External links


PDBe-KB provides an overview of all the structure information available in the PDB for Human 3/info/glycogen" target="_blank">Glycogen 3/info/synthase" target="_blank">synthase 3/info/kinase" target="_blank">kinase-3 beta (GSK3B)

Kata Kunci Pencarian:

• Insulin
• Diabetes gestasional
• Glycogen synthase kinase-3 beta
• GSK-3
• AMP-activated protein kinase
• Lipid emulsion
• Protein kinase A
• Glycogen phosphorylase
• AXIN2
• ILKAP
• Protein kinase B
• AXIN1