- Source: Glycoprotein Ib
Glycoprotein Ib (GPIb), also known as CD42,
is a component of the GPIb-V-IX complex on platelets. The GPIb-V-IX complex binds von Willebrand factor, allowing platelet adhesion and platelet plug formation at sites of vascular injury. Glycoprotein Ibα (GPIbα) is the major ligand-binding subunit of the GPIb-V-IX complex. GPIbα is heavily glycosylated.
It is deficient in the Bernard–Soulier syndrome. A gain-of-function mutation causes platelet-type von Willebrand disease.
Autoantibodies against Ib/IX can be produced in immune thrombocytopenic purpura.
Components include GP1BA and GP1BB.
It complexes with Glycoprotein IX.
References
External links
Glycoprotein+Ib at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Kata Kunci Pencarian:
- Sel punca dewasa
- Glycoprotein Ib
- GP1BA
- Glycoprotein Ib-IX-V complex
- Platelet membrane glycoprotein
- Coagulation
- Bernard–Soulier syndrome
- Von Willebrand factor
- Glycoprotein IX
- BS
- Ristocetin
