• Source: Glycopyrronium bromide/formoterol

Glycopyrronium bromide/formoterol, sold under the brand name Bevespi Aerosphere, is a combination medication used for the maintenance treatment of chronic obstructive pulmonary disease (COPD). It is a combination of glycopyrronium bromide and formoterol. It is inhaled.
The most common side effects include headache, nausea (feeling sick), muscle spasms and dizziness.
Glycopyrronium bromide is a muscarinic receptor antagonist. This means that it blocks muscarinic receptors (targets) in muscle cells in the lungs. Because these receptors help control the contraction of muscles, when glycopyrronium is inhaled, it causes the muscles of the airways to relax, helping to keep the airways open.
Formoterol is a long-acting beta-2 agonist. It works by attaching to receptors known as beta-2 receptors found in the muscles of the airways. When it attaches to these receptors, it causes the muscles to relax, which keeps the airways open.




Medical uses


Glycopyrronium bromide/formoterol is indicated as a maintenance bronchodilator treatment to relieve symptoms in adults with chronic obstructive pulmonary disease (COPD).




History


Glycopyrronium bromide/formoterol was approved for medical use in the United States in April 2016, and in the European Union in December 2018.
It is marketed by AstraZeneca.




References






Further reading


Al-Salama ZT, Frampton JE (September 2019). "Glycopyrronium/Formoterol: A Review in COPD". Drugs. 79 (13): 1455–1466. doi:10.1007/s40265-019-01186-x. PMID 31468315. S2CID 201655987.
D'Urzo AD, Cazzola M, Hanania NA, Buhl R, Maleki-Yazdi MR (2018). "New developments in optimizing bronchodilator treatment of COPD: a focus on glycopyrrolate/formoterol combination formulated by co-suspension delivery technology". Int J Chron Obstruct Pulmon Dis. 13: 2805–2819. doi:10.2147/COPD.S113306. PMC 6135066. PMID 30233171.{{cite journal}}: CS1 maint: overridden setting (link)

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