- Source: Glycoside hydrolase family 5
In molecular biology, 5.180.24.3/info/glycoside" target="_blank">glycoside 5.180.24.3/info/hydrolase" target="_blank">hydrolase 5.180.24.3/info/family" target="_blank">family 5 is a 5.180.24.3/info/family" target="_blank">family of 5.180.24.3/info/glycoside" target="_blank">glycoside hydrolases EC 3.2.1., which are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for 5.180.24.3/info/glycoside" target="_blank">glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.
5.180.24.3/info/glycoside" target="_blank">Glycoside 5.180.24.3/info/hydrolase" target="_blank">hydrolase 5.180.24.3/info/family" target="_blank">family 5 CAZY GH_5 comprises enzymes with several known activities including endoglucanase (EC 3.2.1.4); beta-mannanase (EC 3.2.1.78); exo-1,3-glucanase (EC 3.2.1.58); endo-1,6-glucanase (EC 3.2.1.75); xylanase (EC 3.2.1.8); endoglycoceramidase (EC 3.2.1.123); xanthanase.
The microbial degradation of cellulose and xylans requires several types of enzymes. Fungi and bacteria produces a spectrum of cellulolytic enzymes (cellulases) and xylanases which, on the basis of sequence similarities, can be classified into families. One of these families is known as the cellulase 5.180.24.3/info/family" target="_blank">family A or as the glycosyl hydrolases 5.180.24.3/info/family" target="_blank">family 5. One of the conserved regions in this 5.180.24.3/info/family" target="_blank">family contains a conserved glutamic acid residue which is potentially involved in the catalytic mechanism.
In a recent study using Molecular Dynamics simulations, a considerable correlation between thermal stability and structural rigidity of members of 5.180.24.3/info/family" target="_blank">family 5 with solved structures has been proved.
External links
GH5 in CAZypedia