- Source: GR-55562
GR-55562 is a selective serotonin 5-HT1B and 5-HT1D receptor antagonist. It is one of several selective serotonin 5-HT1B receptor antagonists used in scientific research.
The drug is a silent antagonist of the serotonin 5-HT1B receptor, unlike the related agent GR-127935. GR-55562 has around 10-fold selectivity for the serotonin 5-HT1B receptor over the serotonin 5-HT1D receptor and has only weak affinity for a number of other serotonin receptors.
It is ineffective in attenuating MDMA-induced prosocial behavior in animals. Conversely, the serotonin 5-HT1A receptor antagonist WAY-100635 can abolish MDMA-induced prosocial behavior.
See also
AR-A000002
GR-127935
SB-216641
SB-236057
