- Source: GTPase-activator protein for Ras-like GTPase
gtpase" target="_blank">GTPase-activator protein for Ras-like gtpase" target="_blank">GTPase is a family of evolutionarily related proteins. Ras proteins are membrane-associated molecular switches that bind GTP and GDP and slowly hydrolyze GTP to GDP. This intrinsic gtpase" target="_blank">GTPase activity of ras is stimulated by a family of proteins collectively known as 'GAP' or gtpase" target="_blank">GTPase-activating proteins. As it is the GTP bound form of ras which is active, these proteins are said to be down-regulators of ras.
The Ras gtpase" target="_blank">GTPase-activating proteins are quite large (from 765 residues for sar1 to 3079 residues for IRA2) but share only a limited (about 250 residues) region of sequence similarity, referred to as the 'catalytic domain' or rasGAP domain.
Note: There are distinctly different GAPs for the rap and rho/rac subfamilies of ras-like proteins (reviewed in reference) that do not share sequence similarity with ras GAPs.
Examples
Human genes encoding proteins containing this domain include:
DAB2IP;
GAPVD1;
IQGAP1; IQGAP2; IQGAP3;
NF1;
RASA1; RASA2; RASA3; RASA4; RASAL1; RASAL2;
SYNGAP1;
References
Kata Kunci Pencarian:
- GTPase-activating protein
- GTPase-activator protein for Ras-like GTPase
- Small GTPase
- GTPase
- Rho family of GTPases
- RAS p21 protein activator 1
- Rab (G-protein)
- G protein
- Transforming protein RhoA
- KRAS
