• Source: Guanylate cyclase activator

A guanylate cyclase activator (or "GUCA") is a member of a group of proteins that upregulate guanylate cyclase. GUCA is also known as guanylate cyclase-activating protein (or "GCAP"). Its mutations can be associated with vision defects.
There are five genes involved:

GUCA1A, GUCA1B, GUCA1C
GUCA2A, GUCA2B
There are several therapeutic drugs that act as GUCAs, including linaclotide and plecanatide, which are guanylate cyclase-C receptor agonists. These drugs increase the secretion of bicarbonate and chloride in the colon and potentially relieve visceral hypersensitivity in IBS-C patients.




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External links


Guanylate+Cyclase-Activating+Proteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Kata Kunci Pencarian:

• Natrium azida
• Guanylate cyclase activator
• Guanylate cyclase
• Guanylate cyclase activator 2B
• Soluble guanylyl cyclase
• Riociguat
• Vericiguat
• Guanylate cyclase 2C
• Soluble guanylate cyclase stimulator
• Avenciguat
• Guanylate cyclase-coupled receptor