- Source: Harmane
Harmane (harman) is a heterocyclic amine found in a variety of foods including coffee, sauces, and cooked meat. It is also present in tobacco smoke.
Harmane is related to other alkaloids, harmine and harmaline, found in 1837 in the plant Peganum harmala. The name derives from the Arabic word for the plant, حَرْمَل (ḥarmal).
In humans, harmane is a potent tremor-producing neurotoxin. Harmane has been found to inhibit the early stages of the growth of the malaria parasite in the gut of mosquitoes infected by the bacterium Delftia tsuruhatensis, and can be absorbed by the mosquitoes upon contact.
Chemistry
Harmane is a methylated derivative of β-carboline with the molecular formula C12H10N2.
Sources
In 1962, Poindexter et al. found that there was very little harmane in tobacco, but a significant amount in tobacco smoke. They showed that it is produced from tryptophan by the heat of burning the tobacco.
See also
Harmine
References
Kata Kunci Pencarian:
- Harmane
- Heterocyclic amine
- Essential tremor
- 9-Methyl-β-carboline
- Tobacco smoking
- Elaeagnus angustifolia
- Nicotiana rustica
- Tribulus terrestris
- Tryptoline
- Harmala alkaloid
