• Source: HBG2

Hemoglobin subunit gamma-2 is a protein that in humans is encoded by the HBG2 gene.




Function


The gamma globin genes (HBG1 and HBG2, this gene) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5' - epsilon – gamma-G – gamma-A – delta – beta - 3'.




References






Further reading






External links


Overview of all the structural information available in the PDB for UniProt: P69892 (Hemoglobin subunit gamma-2) at the PDBe-KB.

Kata Kunci Pencarian:

• Daftar gen penyandi protein pada manusia/2
• HBG2
• Fetal hemoglobin
• Human β-globin locus
• Globin
• List of human protein-coding genes 2
• Gamma subunit
• Hemoglobin M disease
• HBG1
• Locus control region
• List of OMIM disorder codes