• Source: HLA-DR1

HLA-DR1 (DR1) is a HLA-DR serotype that recognizes the DRB1*01 gene products. It has been observed to be common among centenarians.




Serology



The serology for the most common DR1 alleles is excellent. The serology for alleles *01:04, *01:06, *01:09, *01:10, *0112, *0115, and *0116 is unknown.




Disease associations






= By serotype

=
DR1 is associated with seronegative-rheumatoid arthritis, penicillamine-induced myasthenia, and schizophrenia. DR1 is increased in patients with systemic sclerosis and arthritis and in ulcerative colitis with patients that have articular manifestations.




= By allele

=
DRB1*01:01 is associated with rheumatoid arthritis, in anti-Jk(a) mediated hemolytic transfusion reactions, foliaceous pemphigus, HTLV-1-associated myelopathy/tropical spastic paraparesis, and lichen planus. In lyme disease arthritis, *01:01 appears to play a role in
presentation of triggering microbial antigens.
DRB1*01:02 is associated with rheumatoid arthritis, in anti-Jk(a) mediated hemolytic transfusion reactions, psoriasis vulgaris, and recurrent respiratory papillomatosis
DRB1*01:03 is associated with colonic Crohn's disease and ulcerative colitis.




= By genotype

=
DRB1*01:01/*0404 and *01:01/*0401 increases risk of mortality in rheumatoid arthritis, with ischemic heart disease and smoking. these same genotypes are associated with rheumatoid vasculitis.




= By haplotype

=
DRB1*01:02:DQB1*05:01 is associated with psoriasis vulgaris and tubulointerstitial nephritis & uveitis syndrome, but is relatively protective against juvenile diabetes.
DR1-DQ5 is associated with tubulointerstitial nephritis & uveitis syndrome.




Rheumatoid arthritis


DR1 are associated with rheumatoid arthritis, and while not the strongest association with the highest risk for early onset arthritis is within the DR4-bearing Native American population. There frequency of DR4-DQ8 haplotypes reach extreme nodal levels. Arthritis has been identified in a pre-Columbian remains from Italy, the affected individual bearing the DRB1*01:01 allele. DRB1*01:01 and most DR4 have in common a 'shared epitope'. In this hypothesis a common region of the beta chain, positions 67 to 74, are common and may be integral to presenting auto-immunological peptides.




Genetic linkage



HLA-DR1 is not genetically linked to DR51, DR52 or DR53, but is linked to HLA-DQ1 and DQ5 serotypes.




References

Kata Kunci Pencarian:

• HLA-DR1
• Rheumatoid arthritis
• HLA-DRB1
• HLA-DR
• Human leukocyte antigen
• Major histocompatibility complex
• HLA-DRA
• HLA-DQ5
• HLA-DRB5
• HLA A1-B8-DR3-DQ2