• Source: Homoquinolinic acid

Homoquinolinic acid (HQA) is a potent excitotoxin that is a conformationally restricted analogue of N-methyl-D-aspartate (NMDA) and a partial agonist of the main/glutamate site of the NMDA receptor, with some selectivity for NR2B subunit-containing receptors. It is approximately equipotent to NMDA and about five times more potent than quinolinic acid as an agonist of the NMDA receptor. HQA has also been found to label a novel yet uncharacterized binding site, which can be distinguished from the NMDA receptor with the use of 2-carboxy-3-carboxymethylquinoline (CCMQ), a selective ligand of the uncharacterized site.




See also


Aspartate
Ibotenic acid
Tetrazolylglycine




References

Kata Kunci Pencarian:

• Homoquinolinic acid
• Glutamic acid
• Muscimol
• 5,7-Dichlorokynurenic acid
• Alanine
• Glycine
• 1-Aminocyclopropane-1-carboxylic acid
• Domoic acid
• Kainate receptor
• Aspartic acid