• Source: Hycanthone

Hycanthone is the schistosomicide approved by the FDA in 1975. It is a metabolite of lucanthone. Hycanthone interferes with parasite nerve function, resulting in paralysis and death. This agent also intercalates into DNA and inhibits RNA synthesis in vitro and shows potential antineoplastic activity.




Anti-schistosomal activity


Hycanthone is shown to be an effective inhibitor of acetylcholinesterase (AChE) from Schistosoma mansoni, but is less potential against AChE from mammalian origin. This might come from differences in the configuration of active center between schistosome and mammalian AChE enzymes.
Hycanthone is shown to intercalate into DNA and inhibit RNA synthesis in vitro. A growing body of evidence has shown that hycathone has an antineoplastic activity.




Toxicity


Hycanthone is a dose-dependent hepatotoxin, causing hepatocellular injury.




Clinical trials


Phase II Study of Chemotherapy with Hycanthone for Advanced Colorectal Carcinoma.
Phase II Chemotherapy with Hycanthone Mesylate and Flagyl for Advanced Malignant Lymphomas (Completed)




Physical properties






References

Kata Kunci Pencarian:

• Hycanthone
• Lucanthone
• List of drugs: Hf–Hz
• Thioxanthone
• Moxidectin
• List of drugs used to treat schistosomiasis
• IARC group 3
• Niridazole
• Schistosoma bovis
• List of MeSH codes (D03)