- Source: Hydrazine (antidepressant)
The hydrazine antidepressants are a group of non-selective, irreversible monoamine oxidase inhibitors (MAOIs) which were discovered and initially marketed in the 1950s and 1960s. Most have been withdrawn due to toxicity, namely hepatotoxicity, but a few still remain in clinical use.
Tranylcypromine, a structurally unrelated MAOI introduced around the same time as the hydrazines, was originally advertised as non-hydrazine as a result of its diminished propensity for causing hepatotoxicity.
List of hydrazine antidepressants
= Marketed
=Legend: ‡ = Withdrawn from the market; † = Partially discontinued; Bolded names indicate major drugs.
= Never marketed
=Carbenzide
Cimemoxin
Domoxin
Metfendrazine
= Parkinson's
=Carbidopa
= Tranquillosedative
=Centazolone
References
López-Muñoz F, Alamo C (2009). "Monoaminergic neurotransmission: the history of the discovery of antidepressants from 1950s until today". Current Pharmaceutical Design. 15 (14): 1563–86. doi:10.2174/138161209788168001. PMID 19442174. Archived from the original on 2013-04-14.{{cite journal}}: CS1 maint: unfit URL (link)
Kata Kunci Pencarian:
- Hydrazine (antidepressant)
- Safrazine
- Phenelzine
- Antidepressant
- Iproniazid
- Monomethylhydrazine
- Isocarboxazid
- Monoamine oxidase inhibitor
- Benmoxin
- Nialamide
