- Source: IBMX
IBMX (3-isobutyl-1-methylxanthine), like other methylxanthine derivatives, is both a:
competitive non-selective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNFα and leukotriene synthesis, and reduces inflammation and innate immunity, and
nonselective adenosine receptor antagonist.
As a phosphodiesterase inhibitor, IBMX has IC50 = 2–50 μM and does not inhibit PDE8 or PDE9.
References
Kata Kunci Pencarian:
- IBMX
- Effect of psychoactive drugs on animals
- 8-Methoxymethyl-3-isobutyl-1-methylxanthine
- Xanthine
- Alcohol (drug)
- Uric acid
- Pentoxifylline
- Caffeine
- Phenolphthalein
- Phosphodiesterase inhibitor
