- Source: Indolepyruvate C-methyltransferase
In enzymology, an indolepyruvate C-methyltransferase (EC 2.1.1.47) is an enzyme that catalyzes the chemical reaction
S-adenosyl-L-methionine + (indol-3-yl)pyruvate
⇌
{\displaystyle \rightleftharpoons }
S-adenosyl-L-homocysteine + (3S)-3-(indol-3-yl)-3-oxobutanoate
Thus, the two substrates of this enzyme are S-adenosyl methionine and (indol-3-yl)pyruvate, whereas its two products are S-adenosylhomocysteine and (3S)-3-(indol-3-yl)-3-oxobutanoate.
Nomenclature
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine: (indol-3-yl)pyruvate C-methyltransferase. Other names in common use include indolepyruvate methyltransferase, indolepyruvate 3-methyltransferase, indolepyruvic acid methyltransferase, and S-adenosyl-L-methionine:indolepyruvate C-methyltransferase. This enzyme participates in tryptophan metabolism.
References
Hornemann U, Speedie MK, Hurley LH, Floss HG (May 1970). "Demonstration of a C-methylating enzyme in cell free extracts of indolmycin-producing Streptomyces griseus". Biochem. Biophys. Res. Commun. 39 (4): 594–9. doi:10.1016/0006-291X(70)90245-7. PMID 5490210.