- Source: IRF1
Interferon regulatory factor 1 is a protein that in humans is encoded by the IRF1 gene.
Function
Interferon regulatory factor 1 was the first member of the interferon regulatory transcription factor (IRF) family identified. Initially described as a transcription factor able to activate expression of the cytokine Interferon beta, IRF-1 was subsequently shown to function as a transcriptional activator or repressor of a variety of target genes. IRF-1 regulates expression of target genes by binding to an interferon stimulated response element (ISRE) in their promoters. The IRF-1 protein binds to the ISRE via an N-terminal helix-turn-helix DNA binding domain, which is highly conserved among all IRF proteins.
Beyond its function as a transcription factor, IRF-1 has also been shown to trans-activate the tumour suppressor protein p53 through the recruitment of its co-factor p300.
IRF-1 has been shown to play roles in the immune response, regulating apoptosis, DNA damage and tumor suppression.
Regulation
It has been shown that the extreme C-terminus of IRF-1 regulates its ability to activate transcription, nanobodies targeting this domain (MF1) are able to increase IRF-1 activity.
Interactions
IRF1 has been shown to interact with:
CHIP
GAGE
HSP70 / HSP90
IRF8
KPNA2
MYD88
PCAF
STAT1
TAT
VEGFR2
REDD2
See also
IRF2
Interferon regulatory factors
References
Further reading
External links
IRF1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
FactorBook IRF1
This article incorporates text from the United States National Library of Medicine, which is in the public domain.