• Source: Irreversible agonist

An irreversible agonist is a type of agonist that binds permanently to a receptor in such a manner that the receptor is permanently activated. It is distinct from a mere (reversible) agonist in that the association of an agonist to a receptor is reversible, whereas the binding of an irreversible agonist to a receptor is, at least in theory, irreversible. Oxymorphazone is an example of an irreversible agonist. In practice, the distinction may be more a matter of degree, in which the binding affinity of an irreversible agonist is some orders of magnitude greater than that of an agonist.




Examples


Oxymorphazone
Metaphit




See also


Agonist
Irreversible antagonist
Irreversible enzyme inhibitor




References

Kata Kunci Pencarian:

• Reseptor terhubung protein G
• Irreversible agonist
• Agonist
• Receptor antagonist
• Irreversible antagonist
• Μ-opioid receptor
• IC50
• RB-64
• Β-Chlornaltrexamine
• Oxymorphazone
• Area under the curve (pharmacokinetics)