- Source: Isovaleramide
Isovaleramide is an organic compound with the formula (CH3)2CHCH2C(O)NH2. The amide derived from isovaleric acid, it is a colourless solid.
Occurrence and biological activity
Isovaleramide is a constituent of valerian root.
In humans, it acts as a mild anxiolytic at lower doses and as a mild sedative at higher dosages. Isovaleramide has been shown to be non-cytotoxic and does not act as a CNS stimulant. It inhibits the liver alcohol dehydrogenases and has a reported LD50 of greater than 400 mg/kg when administered intraperitoneally in mice.
It is a positive allosteric modulator of the GABAA receptor, similarly to isovaleric acid.
References
Kata Kunci Pencarian:
- Isovaleramide
- Menthyl isovalerate
- Valerian (herb)
- List of drugs: Iq–Iz
- C5H11NO
- Alcohol (drug)
- Nitrous oxide
- Propofol
- Sedative
- Alprazolam
