• Source: Juxtaglomerular cell

Juxtaglomerular cells (JG cells), also known as juxtaglomerular granular cells are cells in the kidney that synthesize, store, and secrete the enzyme renin. They are specialized smooth muscle cells mainly in the walls of the afferent arterioles (and some in the efferent arterioles) that deliver blood to the glomerulus. In synthesizing renin, they play a critical role in the renin–angiotensin system and thus in autoregulation of the kidney.
Juxtaglomerular cells secrete renin in response to a drop in pressure detected by stretch receptors in the vascular walls, or when stimulated by macula densa cells. Macula densa cells are located in the distal convoluted tubule, and stimulate juxtaglomerular cells to release renin when they detect a drop in chloride concentration in tubular fluid. Together, juxtaglomerular cells, extraglomerular mesangial cells and macula densa cells comprise the juxtaglomerular apparatus.
In appropriately stained tissue sections, juxtaglomerular cells are distinguished by their granulated cytoplasm.
The juxtaglomerular cell is a cell that is located near the glomerulus, hence its name.
Similar to cardiac tissue, juxtaglomerular cells harbor β1 adrenergic receptors. When stimulated by epinephrine or norepinephrine, these receptors induce the secretion of renin. These cells also respond directly to a decrease in systemic blood pressure which is manifested as a lower renal perfusion pressure.




See also


Juxtaglomerular cell tumor
Juxtaglomerular apparatus
List of distinct cell types in the adult human body




References

Kata Kunci Pencarian:

• Hati
• Juxtaglomerular cell
• Juxtaglomerular apparatus
• Juxtaglomerular cell tumor
• Extraglomerular mesangial cell
• Renin
• List of human cell types derived from the germ layers
• List of human cell types
• Macula densa
• Nephron
• Renin–angiotensin system