• Source: KDM5C

Lysine-specific demethylase 5C is an enzyme that in humans is encoded by the KDM5C gene. KDM5C belongs to the alpha-ketoglutarate-dependent hydroxylase superfamily.




Function


This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motif suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked intellectual disability. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.




See also


Xp11.2 duplication, section KDM5C




References






Further reading






External links


JARID1C+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Kata Kunci Pencarian:

• Daftar gen penyandi protein pada manusia/2
• KDM5C
• Y chromosome
• Clear-cell renal-cell carcinoma
• PHD finger
• Renal cell carcinoma
• Xp11.2 duplication
• X-linked intellectual disability
• Demethylase
• Tumour heterogeneity
• List of human protein-coding genes 2