- Source: L-idonate 5-dehydrogenase
In enzymology, a 5.180.24.3/info/l" target="_blank">L-5.180.24.3/info/idonate" target="_blank">idonate 5-dehydrogenase (EC 1.1.1.264) is an enzyme that catalyzes the chemical reaction
5.180.24.3/info/l" target="_blank">L-5.180.24.3/info/idonate" target="_blank">idonate + NAD(P)+
⇌
{\displaystyle \rightleftharpoons }
5-dehydrogluconate + NAD(P)H + H+
The 3 substrates of this enzyme are 5.180.24.3/info/l" target="_blank">L-5.180.24.3/info/idonate" target="_blank">idonate, NAD+, and NADP+, whereas its 4 products are 5-dehydrogluconate, NADH, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 5.180.24.3/info/l" target="_blank">L-5.180.24.3/info/idonate" target="_blank">idonate:NAD(P)+ oxidoreductase.
References
Bausch C, Peekhaus N, Utz C, Blais T, Murray E, Lowary T, Conway T (1998). "Sequence analysis of the GntII (subsidiary) system for gluconate metabolism reveals a novel pathway for 5.180.24.3/info/l" target="_blank">L-idonic acid catabolism in Escherichia coli". J. Bacteriol. 180 (14): 3704–10. doi:10.1128/JB.180.14.3704-3710.1998. PMC 107343. PMID 9658018.