• Source: Leucyl-tRNA synthetase

Leucyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the LARS gene.




Function


This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginyl-tRNA synthetase through its C-terminal domain. Alternatively spliced transcript variants of this gene have been found; however, their full-length nature is not known.




Interactions


Leucyl-tRNA synthetase has been shown to interact with EEF1G.




Inhibitors


BC-LI-0186
Tavaborole




See also


Leucine-tRNA ligase




References






Further reading

Kata Kunci Pencarian:

• Aminoacyl tRNA synthetase
• Leucyl-tRNA synthetase
• RARS (gene)
• Tavaborole
• Leucine—tRNA ligase
• Methionine—tRNA ligase
• Expanded genetic code
• TARS (gene)
• Leucine
• BC-LI-0186